Immune thrombotic thrombocytopenic purpura in older patients: Results from the Spanish TTP Registry (REPTT)

Author:

Gómez‐Seguí I.1ORCID,Francés Aracil E.2,Mingot‐Castellano M. E.3ORCID,Vara Pampliega M.4,Goterris Viciedo R.5,García Candel F.6,Pascual Izquierdo C.7,del Río Garma J.8ORCID,Guerra Domínguez L.9,Vicuña Andrés I.10,Garcia‐Arroba Peinado J.11,Zalba Marcos S.12,Vidan Estévez J. M.13,González Arias E.14,Campuzano Saavedra V.15,García Gala J. M.16,Ortega Sanchez S.17,Martínez Nieto J.18,Pardo Gambarte L.19,Solé Rodríguez M.20,Fernández‐Docampo M.21,Avila Idrovo L. F.22,Hernández L.23,Cid J.24ORCID,de la Rubia Comos J.125ORCID,

Affiliation:

1. H. Universitario y Politécnico La Fe Valencia Spain

2. H. Doctor Peset Valencia Spain

3. Hematology Department, Instituto de Biomedicina de Sevilla H. U. Virgen del Rocio Sevilla Spain

4. H. Universitario Cruces Barakaldo Spain

5. H. Clínico Valencia Spain

6. H. U. Virgen de la Arrixaca Murcia Spain

7. H. G. U. Gregorio Marañón Madrid Spain

8. Complejo Hospitalario Universitario de Orense Ourense Spain

9. Hospital Dr. Negrín Las Palmas de Gran Canaria Spain

10. H. U. de La Princesa Madrid Spain

11. H. Joan XXIII Tarragona Spain

12. H. Navarra Pamplona Spain

13. H. de León León Spain

14. H. G. de Villalba Madrid Spain

15. H. U. de Burgos Burgos Spain

16. H. Central de Asturias Asturias Spain

17. Banc de Sang i Teixits, L'Hospitalet de Llobregat Barcelona Spain

18. Instituto de Investigación Biomédica del Hospital Clínico San Carlos Madrid Spain

19. Fundación Jiménez Diaz Madrid Spain

20. H. Juan Ramón Jiménez Huelva Spain

21. H. Universitario A Coruña A Coruña Spain

22. H. U. de Canarias Canarias Spain

23. H. G. U. de Alicante Alicante Spain

24. H. Clínic Barcelona Spain

25. Hematology Department Universidad Católica “San Vicente Mártir” Valencia Spain

Abstract

SummaryImmune thrombotic thrombocytopenic purpura (iTTP) is an ultra‐rare disease that seldom occurs in the elderly. Few reports have studied the clinical course of iTTP in older patients. In this study, we have analysed the clinical characteristics at presentation and response to therapy in a series of 44 patients with iTTP ≥60 years at diagnosis from the Spanish TTP Registry and compared them with 209 patients with <60 years at diagnosis from the same Registry. Similar symptoms and laboratory results were described in both groups, except for a higher incidence of renal dysfunction among older patients (23% vs. 43.1%; p = 0.008). Front‐line treatment in patients ≥60 years was like that administered in younger patients. Also, no evidence of a difference in clinical response and overall survival was seen in both groups. Of note, 14 and 25 patients ≥60 years received treatment with caplacizumab and rituximab, respectively, showing a favourable safety and efficacy profile, like that observed in patients <60 years.

Publisher

Wiley

Subject

Hematology

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