Presumptive phenobarbital‐induced systemic lupus erythematosus in a domestic dog

Author:

Phillips Erin1,Kornya Matthew1ORCID,Collier Allison1,Barry Maureen1,Morrison Katherine2,Reggeti Felipe3

Affiliation:

1. Department of Clinical Studies, Ontario Veterinary College University of Guelph Guelph Ontario Canada

2. Department of Pathobiology, Ontario Veterinary College University of Guelph Guelph Ontario Canada

3. Animal Health Laboratories, Laboratory Services Division University of Guelph Guelph Ontario Canada

Abstract

AbstractCase DescriptionWe describe a case of presumptive acquired systemic lupus erythematosus secondary to phenobarbital administration in a dog, which resolved with withdrawal of the drug.Clinical FindingsA 3.5 year‐old poodle presented to a veterinary teaching hospital for Tier 1 idiopathic epilepsy and was treated with phenobarbital. The dog experienced fever, multiple cytopenias, and proteinuria in conjunction with a positive antinuclear antibody (ANA) titer.DiagnosticsSerial CBCs, urine protein : creatinine ratios, and sternal bone marrow aspirates were performed to evaluate improvement.Treatment and OutcomePhenobarbital was withdrawn and levetiracetam initiated. All abnormalities resolved with supportive care, without initiation of immunosuppressive drugs. All cytopenias and proteinuria resolved and ANA test results became negative within 3 months. The patient recovered and did well clinically.Clinical RelevanceSystemic lupus erythematosus is a disease of multiple autoimmune syndromes occurring concurrently or sequentially in conjunction with the presence of circulating ANA. It has been well described in dogs as an idiopathic condition, but in human medicine may occur secondary to drug reactions (drug‐associated lupus) including as a reaction to phenobarbital. The findings in our case are consistent with the criteria for drug‐induced lupus in humans and we suggest it as the first report of phenobarbital‐induced lupus in a dog.

Publisher

Wiley

Subject

General Veterinary

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Canine systemic immunologic diseases;The Immunology of the Dog;2024

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