Final results from a Phase 3, long‐term, open‐label, repeat‐dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy-Reference-Cited by-同舟云学术

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Final results from a Phase 3, long‐term, open‐label, repeat‐dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy

Published:2021-08-21 Issue:10 Volume:62 Page:2485-2495
ISSN:0013-9580
Container-title:Epilepsia
language:en
Short-container-title:Epilepsia

Author:

Wheless James W.¹^ORCID,Miller Ian²^ORCID,Hogan R. Edward³^ORCID,Dlugos Dennis⁴,Biton Victor⁵,Cascino Gregory D.⁶,Sperling Michael R.⁷^ORCID,Liow Kore⁸,Vazquez Blanca⁹,Segal Eric B.¹⁰,Tarquinio Daniel¹¹,Mauney Weldon¹²,Desai Jay¹³,Rabinowicz Adrian L.¹⁴,Carrazana Enrique¹⁴^ORCID,

Affiliation:

1. Le Bonheur Children's Hospital University of Tennessee Health Science Center Memphis Tennessee USA

2. Formerly Nicklaus Children's Hospital Miami Florida USA

3. Washington University in St. Louis St. Louis Missouri USA

4. Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

5. Arkansas Epilepsy Program Little Rock Arkansas USA

6. Mayo Clinic Rochester Minnesota USA

7. Thomas Jefferson University Philadelphia Pennsylvania USA

8. Hawaii Pacific Neuroscience Honolulu Hawaii USA

9. New York University, Comprehensive Epilepsy Center New York New York USA

10. Hackensack University Medical Center and Northeast Regional Epilepsy Group Hackensack New Jersey USA

11. Center for Rare Neurological Diseases Atlanta Georgia USA

12. Northwest Florida Clinical Research Group Gulf Breeze Florida USA

13. Children's Hospital of Los Angeles Los Angeles California USA

14. Neurelis San Diego California USA

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.17041

Reference35 articles.

1. Burden of Seizure Clusters on Patients With Epilepsy and Caregivers

2. The Association Between Seizure Clustering and Convulsive Status Epilepticus in Patients with Intractable Complex Partial Seizures

3. Seizure clusters: A common, understudied and undertreated phenomenon in refractory epilepsy

4. An Open-Label Study of Repeated Use of Diazepam Rectal Gel (Diastat) for Episodes of Acute Breakthrough Seizures and Clusters: Safety, Efficacy, and Tolerance

5. Seizure cluster: Definition, prevalence, consequences, and management

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1. Treatment of prolonged seizure with diazepam nasal spray: An exploratory post hoc cohort analysis;Epilepsy & Behavior;2024-10

2. A Phase 1, Randomized, Open-label, Three-period Crossover Study to Evaluate Pharmacokinetics, Dose Proportionality, and Safety After Single Intranasal Administration of Diazepam Nasal Spray (NRL-1) in Healthy Japanese Participants;Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics;2024-07-31

3. Short-Term Impact of Seizures and Mitigation Opportunities;Current Neurology and Neuroscience Reports;2024-06-28

4. Intranasal Delivery of Medications for the Treatment of Neurologic Conditions: A Pharmacology Update;Journal of Neuroscience Nursing;2024-06-11

5. Diazepam nasal spray administration is effective to control seizure clusters irrespective of time of day;Frontiers in Neurology;2024-05-24

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