Unexpectedly prolonged washout period of exogenous testosterone after discontinuation of intramuscular testosterone undecanoate depot injection (Nebido®or Reandron®) in men with congenital hypogonadotrophic hypogonadism

Author:

Gan Earn H.12,Bouloux Pierre-Marc3,Quinton Richard12

Affiliation:

1. Endocrine Unit; Newcastle-upon-Tyne Hospitals; Newcastle-upon-Tyne UK

2. Endocrine Research Unit; Institute of Genetic Medicine; University of Newcastle-upon-Tyne; Newcastle-upon-Tyne UK

3. Centre for Neuroendocrinology (Royal Free Campus); University College London; London UK

Publisher

Wiley

Subject

Endocrinology, Diabetes and Metabolism,Endocrinology

Reference9 articles.

1. Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: a phase II study;Eckardstein;Journal of Andrology,2002

2. Intramuscular testosterone undecanoate: pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism;Schubert;Journal of Clinical Endocrinology & Metabolism,2004

3. IPASS: a study on the tolerability and effectiveness of injectable testosterone undecanoate for the treatment of male hypogonadism in a worldwide sample of 1,438 men;Zitzmann;Journal of Sexual Medicine,2013

4. Rate, extent, and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis;Liu;Lancet,2006

5. Merck Sharp & Dohme Corp. a subsidiary of Merck & Co. Inc A phase III, multi-center, open label, uncontrolled trial to investigate the efficacy and safety of MK-8962 (corifollitropin alfa) in combination with human Chorionic Gonadotropin (hCG) in inducing increased testicular volume and spermatogenesis in adult men with hypogonadotropic hypogonadism who remain azoospermic when treated with hCG alone ClinicalTrials.gov http://clinicaltrials.gov/show/NCT01709331

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