Affiliation:
1. Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran
2. Laser and Plasma Research Institute Shahid Beheshti University Tehran Iran
3. Physics Department of Shahid Beheshti University Tehran Iran
Abstract
AbstractBackgroundSeborrheic keratoses (SK) is a benign epithelial skin tumor and plasma exeresis is a new technique.AimsTo compare the efficacy and safety of plasma exeresis and cryotherapy for treating SK.MethodsThis study is a randomized controlled trial (RCT). One side of each patient was randomly treated with plasma exeresis (peak‐to‐peak voltage of 3.44 kV and a frequency of 62.5 kHz) and the other side with cryotherapy.ResultsThirty‐five males were enrolled. At week 3, 37.1 % (N = 13) of lesions treated by plasma exeresis were clear, which was higher than those treated by cryotherapy 17.1% (N = 6). However, this difference was not significant (p‐value: 0.06). At week 6, 16 (57.1 %) out of 28 remaining lesions, treated by plasma exeresis were clear, which was significantly higher (p‐value: 0.005) than those completely cleared by cryotherapy in 6 out of 29 remaining lesions (20.7%).The mean physician assessment scale score was significantly reduced in both groups in the second follow‐up (plasma group first follow‐up 0.91 ± 0.89 vs. second follow‐up 0.5 ± 0.64 and p‐value: 0.0031; cryo group first follow‐up 1.4 ± 0.84 vs. second follow‐up 1.1 ± 0.72 and p‐value: 0.0002).Regarding side effects, no significant difference was seen (p = 0.438). The most common complications in the plasma and cryotherapy groups were erythema (10/19, 52.63%) and hypo pigmentation (5/13, 38.46%).ConclusionsBoth cryotherapy and plasma exeresis are effective. We observed a significantly higher cleared lesions treated with plasma exeresis in 6 weeks and after two sessions.
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