Affiliation:
1. Department of Oral and Maxillofacial Surgery, School of Dentistry Aichi‐Gakuin University Nagoya Japan
2. Department of Oral and Maxillofacial Surgery Nagoya Ekisaikai Hospital Nagoya Japan
Abstract
AbstractObjectiveTo evaluate the preoperative haemoglobin, albumin, lymphocyte, and platelet score as a prognostic indicator in oral squamous cell carcinoma treated by radical surgery.Subjects and MethodsPatients (83 men, 32 women; 65.80 ± 11.47 years) who underwent radical surgery between 2012 and 2022 were included. Factors affecting overall survival and disease‐free survival according to the haemoglobin, albumin, lymphocyte, and platelet score were examined. Patients were categorised into low‐ and high‐score groups using optimal cut‐off values obtained from receiver operating characteristic curve analysis.ResultsThe low‐score group had poorer overall and disease‐free survival (p < 0.001 each). Multivariate analysis identified alcohol consumption (hazard ratio [HR], 3.83; 95% confidence interval [CI]: 1.56–9.41, p = 0.003); vascular invasion (HR, 3.97; 95% CI: 1.60–9.85, p = 0.003); and the haemoglobin, albumin, lymphocyte, and platelet score (HR, 0.39; 95% CI: 0.20–0.78, p = 0.007) as independent prognostic factors for overall survival and vascular (HR, 3.66; 95% CI: 1.79–7.50, p < 0.001) and lymphovascular (HR, 2.44; 95% CI: 1.36–4.41, p = 0.003) invasion as independent prognostic factors for disease‐free survival.ConclusionThe preoperative haemoglobin, albumin, lymphocyte, and platelet score may be a significant prognostic factor for patients with oral squamous cell carcinoma undergoing radical surgery.