The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats

Author:

Mach John123,Huizer - Pajkos Aniko12,Mitchell Sarah J.4,McKenzie Catriona5,Phillips Leo6,Kane Alice123,Jones Brett37,de Cabo Rafael4,Cogger Victoria38,Le Couteur David G.38,Hilmer Sarah N.123

Affiliation:

1. Laboratory of Ageing and Pharmacology; Kolling Institute of Medical Research; Sydney NSW Australia

2. Department of Clin Pharmacol and Aged Care; Royal North Shore Hosp; Sydney NSW Australia

3. Sydney Medical School; Univ of Sydney; Sydney NSW Australia

4. Translational Gerontology Branch; National Institute on Aging; National Institute of Health; Baltimore Maryland USA

5. Pathology Department; Royal Prince Alfred Hosp; Sydney NSW Australia

6. Mass Spec Imaging and Proteomics Laboratory; Kolling institute of Medical Research; Sydney NSW Australia

7. Department of Gastroenterology; Kolling Institute of Medical Research; Sydney NSW Australia

8. Ageing and Alzheimers Institute; Centre for Education and Research on Ageing and Anzac Research Institute; Concord Hospital and University of Sydney; Sydney NSW Australia

Funder

National Health and Medical Research Council

The Geoff and Elaine Penney Ageing Research Unit, Royal North Shore Hospital

The Intramural Research Program of the National Institute on Aging

National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference57 articles.

1. WHO World Health Organization: Fact Sheet No.104: Tuberculosis 2015 http://www.who.int/mediacentre/factsheets/fs104/en/

2. Tuberculosis among older adults - time to take notice;Negin;Int. J. Infect. Dis.,2015

3. Institute of Health Metrics and Evaluation Global Burden of Disease; 2014 http://www.healthdata.org/search-gbd-data?s=Tuberculosis

4. Isoniazid-related hepatitis: a U.S. Public Health Service cooperative surveillance study;Kopanoff;Am. Rev. Respir. Dis.,1978

5. Evaluation of risk factors for antituberculosis treatment induced hepatotoxicity;Singla;Indian J. Med. Res.,2010

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