KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia
Author:
Affiliation:
1. Karyopharm Therapeutics; Natick; MA; USA
Publisher
Wiley
Subject
Hematology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bjh.12231/fullpdf
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3. A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export;Daelemans;Proceedings of the National Academy of Sciences of the United States of America,2002
4. BH3 profiling - Measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions;Del Gaizo Moore;Cancer Letters,2012
5. Structural basis for leucine-rich nuclear export signal recognition by CRM1;Dong;Nature,2009
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