NLRP2 in health and disease

Author:

Zhang Tongtong1ORCID,Xing Fei12,Qu Mingcui1,Yang Zhihu1,Liu Yafei1,Yao Yongchao1,Xing Na12

Affiliation:

1. Department of Anesthesiology, Pain and Perioperative Medicine The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China

2. Henan Province International Joint Laboratory of Pain Cognition and Emotion Zhengzhou Henan China

Abstract

AbstractNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod‐like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its ‘specific’ functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproductive system is unclear. Here, we highlight the most current progress on NLRP2 in inflammasome activation, effector function and regulation of nuclear factor‐κB. And we discuss functions of NLRP2 in inflammatory diseases, reproductive disorders and the potential implication of NLRP2 in human diseases.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

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