Affiliation:
1. Division of Dermatology, Montefiore Medical Center Albert Einstein College of Medicine Bronx New York USA
2. D. Samuel Gottesman Library Albert Einstein College of Medicine Bronx New York USA
Abstract
AbstractCutaneous adverse events are commonly reported in adult patients with chronic myeloid leukemia (CML) receiving tyrosine kinase inhibitors (TKIs); however, little is known about the cutaneous reactions in children receiving TKIs for CML. As pediatric patients may require lifelong TKI therapy, it is essential to understand the wide range of potential cutaneous toxicities. We examined all case studies, cohort studies, and clinical trials in PubMed/MEDLINE and Embase that reported cutaneous reactions to first‐, second‐, and third‐generation TKIs in children 18 years or younger with CML. This review article focuses on the TKI drug types and doses, patient demographic characteristics, features of skin reactions, and clinical outcomes.
Subject
Dermatology,Pediatrics, Perinatology and Child Health