Skin reactions to tyrosine kinase inhibitors in pediatric patients with chronic myeloid leukemia

Author:

Toker Michelle1ORCID,Jaller Jose A.1,Delbourgo Patton Caroline2,Wu Benedict1

Affiliation:

1. Division of Dermatology, Montefiore Medical Center Albert Einstein College of Medicine Bronx New York USA

2. D. Samuel Gottesman Library Albert Einstein College of Medicine Bronx New York USA

Abstract

AbstractCutaneous adverse events are commonly reported in adult patients with chronic myeloid leukemia (CML) receiving tyrosine kinase inhibitors (TKIs); however, little is known about the cutaneous reactions in children receiving TKIs for CML. As pediatric patients may require lifelong TKI therapy, it is essential to understand the wide range of potential cutaneous toxicities. We examined all case studies, cohort studies, and clinical trials in PubMed/MEDLINE and Embase that reported cutaneous reactions to first‐, second‐, and third‐generation TKIs in children 18 years or younger with CML. This review article focuses on the TKI drug types and doses, patient demographic characteristics, features of skin reactions, and clinical outcomes.

Publisher

Wiley

Subject

Dermatology,Pediatrics, Perinatology and Child Health

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