A novel non‐bile acid FXR agonist EDP‐305 potently suppresses liver injury and fibrosis without worsening of ductular reaction

Author:

An Ping12ORCID,Wei Guangyan13,Huang Pinzhu14ORCID,Li Wenda15,Qi Xiaolong16,Lin Yi1,Vaid Kahini A.1,Wang Jun7,Zhang Shucha8,Li Yang8,Or Yat Sun8,Jiang Li‐Juan8,Popov Yury V.1ORCID

Affiliation:

1. Divison of Gastroenterology and Hepatology Beth Israel Deaconess Medical CenterHarvard Medical School Boston MA USA

2. Division of Gastroenterology and Hepatology Renmin HospitalWuhan University Wuhan China

3. Department of Radiation Oncology The First Affiliated HospitalSun Yat‐sen University Guangzhou China

4. Department of Colon and Rectum Surgery The Sixth Affiliated HospitalSun Yat-sen University Guangzhou China

5. Department of Hepatobiliary Surger Sun Yat-sen Memorial HospitalSun Yat‐sen University Guangzhou China

6. Institute of Portal Hypertension The First Hospital of Lanzhou University Lanzhou China

7. Division of Neurosurgery Renmin HospitalWuhan University Wuhan China

8. Enanta Pharmaceuticals, Inc. Watertown MA USA

Funder

PSC Partners Seeking a Cure

Beth Israel Deaconess Medical Center

National Natural Science Foundation of China

Publisher

Wiley

Subject

Hepatology

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1. Role of FXR in the development of NAFLD and intervention strategies of small molecules;Archives of Biochemistry and Biophysics;2024-07

2. Unravelling the therapeutic landscape of bile acid-based therapies in gastrointestinal disorders;Saudi Journal of Gastroenterology;2024-05-06

3. Cellular Interactions and Crosstalk Facilitating Biliary Fibrosis in Cholestasis;Cellular and Molecular Gastroenterology and Hepatology;2024

4. The liver sinusoid in chronic liver disease: NAFLD and NASH;Sinusoidal Cells in Liver Diseases;2024

5. FXR agonists in NASH treatment;Journal of Hepatology;2023-11

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