NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease

Author:

Zhu X.1,Wang X.-D.1,Chao K.2,Zhi M.2,Zheng H.1,Ruan H.-L.3,Xin S.1,Ding N.2,Hu P.-J.2,Huang M.1,Gao X.2

Affiliation:

1. Institute of Clinical Pharmacology; School of Pharmaceutical Sciences; Sun Yat-sen University; Guangzhou China

2. Department of Gastroenterology; the Sixth Affiliated Hospital; Sun Yat-sen University; Guangzhou China

3. School of Public Health; Guangzhou Medical University; Guangzhou China

Funder

National Nature Science Fund of China

Science and Technology Planning Project of Guangdong Province, China

Publisher

Wiley

Subject

Pharmacology (medical),Gastroenterology,Hepatology

Reference52 articles.

1. Azathioprine or 6-mercaptopurine for inducing remission of Crohn's disease;Sandborn;Cochrane Database Syst Rev,2000

2. Azathioprine for maintaining remission of Crohn's disease;Pearson;Cochrane Database Syst Rev,2000

3. Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease;Chande;Cochrane Database Syst Rev,2013

4. The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review;Fraser;Gut,2002

5. Safety of thiopurine therapy in inflammatory bowel disease: long-term follow-up study of 3931 patients;Chaparro;Inflamm Bowel Dis,2013

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