Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes-Reference-Cited by-同舟云学术

Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes

Published:2011-05-16 Issue:6 Volume:28 Page:681-684
ISSN:0742-3071
Container-title:Diabetic Medicine
language:en
Short-container-title:Diabetic Medicine

Author:

Edghill E. L.¹,Khamis A.¹,Weedon M. N.²,Walker M.³,Hitman G. A.⁴,McCarthy M. I.⁵⁶⁷,Owen K. R.⁵⁶,Ellard S.¹,T Hattersley A.¹,Frayling T. M.²

Affiliation:

1. Institute of Biomedical and Clinical Science

2. Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter

3. Institute of Cellular Medicine, Newcastle University

4. Department of Diabetes and Metabolism, Barts and the London NHS Trust and School of Medicine and Dentistry, London

5. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford

6. Oxford NIHR Biomedical Research Centre, Churchill Hospital

7. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1464-5491.2011.03269.x

Reference19 articles.

1. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

2. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

3. New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function

4. Detailed Investigation of the Role of Common and Low-Frequency WFS1 Variants in Type 2 Diabetes Risk

5. Low Frequency Variants in the Exons Only Encoding Isoform A of HNF1A Do Not Contribute to Susceptibility to Type 2 Diabetes

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeted gene panel analysis of Japanese patients with maturity‐onset diabetes of the young‐like diabetes mellitus: Roles of inactivating variants in the ABCC8 and insulin resistance genes;Journal of Diabetes Investigation;2022-12-12

2. Study of the frequency and clinical features of maturity-onset diabetes in the young in the pediatric and adolescent diabetes population in Iran;Journal of Pediatric Endocrinology and Metabolism;2022-09-15

3. 100 YEARS OF INSULIN: A brief history of diabetes genetics: insights for pancreatic beta-cell development and function;Journal of Endocrinology;2021-09-01

4. Monogenic diabetes: a gateway to precision medicine in diabetes;Journal of Clinical Investigation;2021-02-01

5. Congenital Diabetes: Comprehensive Genetic Testing Allows for Improved Diagnosis and Treatment of Diabetes and Other Associated Features;Current Diabetes Reports;2018-06-13