Preparation and efficacy verification of three‐dimensional printed partitioned multi‐effect precision‐care gel facial mask

Author:

Chen Junli1,Liufu Chunqiao1,Zhang Wenfang1,Luo Chunhong2,Fu Kaixia1,Lin Jianchang1,Liang Jiawei1,Yang Wei3,Song Fenglan45,Yang Fan1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Advanced Drug Delivery and Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, The Center of Teaching Experiments Guangdong Pharmaceutical University Guangzhou Guangdong China

2. Guangzhou Baiyun Meiwan Testing Limited Company Guangzhou Guangdong China

3. The Center for Drug Research and Development Guangdong Pharmaceutical University Guangzhou Guangdong China

4. Experimental Center of Zhongshan Campus Guangdong Pharmaceutical University Zhongshan Guangdong China

5. Guangdong Cosmetics Engineering and Technology Research Center Guangdong Pharmaceutical University Guangzhou Guangdong China

Abstract

AbstractObjectiveA partition multi‐effect precision‐care gel facial mask conforming to facial skin characteristics was prepared using three‐dimensional (3D) printing technology.MethodsFirst, the hydrogel matrix and humectant of a 3D‐printed gel for facial masks were screened, and three 3D‐printed gels of arbutin, hexapeptide, and salicylic acid were prepared with whitening, wrinkle removal, and oil control functions, respectively. Skin irritation tests were performed on the gels. Physicochemical properties such as pH, heat and cold tolerance were evaluated. The efficacy of three 3D‐printed gels was assessed by measuring melanin value, wrinkle depression score, and oil secretion. Finally, the facial mask model design and printing parameters were studied, and a partition multi‐effect precision‐care gel facial mask was printed in line with facial skin characteristics.ResultsFor the 3D‐printed facial mask, the gel prescription with 2% hydroxyethyl cellulose gel as matrix and 7% glycerol as humectant was the best. The prepared 3D‐printed gel did not irritate the human skin, and its physicochemical properties met the Chinese facial mask industry standard (QB/T2872‐2017). We showed that three types of 3D‐printed gels containing arbutin, hexapeptide, and salicylic acid could be applied to the corresponding parts of the face to solve different problems, such as facial skin dullness, wrinkles, and oil secretion. Therefore, according to facial physiological characteristics, the facial mask model was designed for the forehead and nasolabial fold, which needs to be anti‐wrinkled; the cheek, which needs to be whitened; and the nose and chin, which need oil control. The optimal printing parameters were 0.26 mm nozzle diameter, 90 mm/s printing speed, 30% filling density, 140% wire extrusion ratio, and 0.25 mm layer height. Different skin care effects can be achieved using a three‐nozzle printer to print arbutin, hexapeptide, or salicylic acid gel on the mask's forehead and nasolabial fold, cheek, and nose and chin, respectively.ConclusionThe 3D‐printed partition multi‐effect care gel facial mask prepared according to the skin features of different parts of the face can overcome the problem of the single skincare effect of the mass‐produced facial masks.

Publisher

Wiley

Subject

Colloid and Surface Chemistry,Dermatology,Drug Discovery,Pharmaceutical Science,Aging,Chemistry (miscellaneous)

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