Affiliation:
1. Departamento de Morfología, Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Mexico City Mexico
2. Departamento de Hematología, Unidad de Investigación de Medicina Traslacional en Enfermedades Hemato Oncológicas, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social Unidad Médica de Alta Especialidad Mexico City Mexico
3. Departamento de Patología Unidad Médica de Alta Especialidad, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Seris y Zaachila S/N Colonia La Raza Mexico City Mexico
Abstract
AbstractDiffuse large B‐cell lymphoma (DLBCL) is the most frequent lymphoma. MIC‐A and MIC‐B are the natural ligands for NKG2D, a receptor expressed in NK cells. MIC‐A soluble isoforms (sMICA) have been described in different malignancies.ObjectivesTo analyze lymphocyte subsets and sMIC‐A in germinal center DLBCL.Materials and MethodssMICA, sMICB, and peripheral blood lymphocyte subsets (CD4+, CD8+, NK, NKT, γδ T cells, and dendritic cells) were analyzed in 59 patients and 60 healthy donors.ResultsPatients had decreased numbers of type 1 and type 2 dendritic cells, NK, iNKT, CD4 T, and CD8 T cells, and higher levels of sMIC‐A. The 2‐year PFS for high IPI scores and high sMIC‐A was 24% and 28%, respectively. The 2‐year OS for high IPI scores and high sMIC‐A was 42% and 33%. The 2‐year PFS and OS for patients not achieving response to treatment were 0% and 10%, respectively. The MICPI score (one point each for high IPI score and high sMIC‐A) showed that those patients summing two points had worse PSF and OS.ConclusionsPatients with DLBCL have decreased numbers of peripheral lymphocyte subsets and high levels of sMIC‐A. The addition of sMIC‐A to IPI could improve its prognostic relevance.