Clinical Pharmacology and Translational Aspects of Bispecific Antibodies

Author:

Trivedi A1,Stienen S2,Zhu M1,Li H1,Yuraszeck T1,Gibbs J13,Heath T1,Loberg R1,Kasichayanula S14

Affiliation:

1. Amgen Inc.; Thousand Oaks California USA

2. Amgen Research (Munich); Munich Germany

3. Current address: AbbVie Inc.; North Chicago Illinois USA

4. Current Address: AbbVie Inc.; South San Francisco California USA

Funder

Amgen

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference85 articles.

1. U.S. Department of Health and Human Services FaDA Center for Drug Evaluation and Research (CDER) Codevelopment of Two or More New Investigational Drugs for Use in Combination http://wwwfdagov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/defaulthtm 2013

2. A novel bispecific antibody targeting EGFR and cMet is effective against EGFR inhibitor-resistant lung tumors;Moores;Cancer Res.,2016

3. The application of mathematical modelling to the design of bispecific monoclonal antibodies;Steeg;mAbs.,2016

4. A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications;Byrne;Trends Biotechnol.,2013

5. Engineered proteins with desired specificity: DARPins, other alternative scaffolds and bispecific IgGs;Jost;Current Opin. Struct. Biol.,2014

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