Elevated microRNA-34a in obesity reduces NAD+levels and SIRT1 activity by directly targeting NAMPT

Author:

Choi Sung-E1,Fu Ting1,Seok Sunmi1,Kim Dong-Hyun1,Yu Eunkyung1,Lee Kwan-Woo2,Kang Yup3,Li Xiaoling4,Kemper Byron1,Kemper Jongsook K.1

Affiliation:

1. Department of Molecular and Integrative Physiology; University of Illinois at Urbana-Champaign; Urbana IL 61801 USA

2. Department of Endocrinology and Metabolism; Ajou University School of Medicine; Suwon 442-749 Korea

3. Institute for Medical Science; Ajou University School of Medicine; Suwon 442-749 Korea

4. Laboratory of Signal Transduction; National Institute of Environmental Health Sciences; Research Triangle Park NC 27709 USA

Publisher

Wiley

Subject

Cell Biology,Aging

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