A sneak peek into chronic glucose exposure and insulin secretion impairment through translatome

Abstract

Diabetes is an epidemic caused by a multitude of factors. Despite the studies attempting to unravel its mechanism, there is still more to discover about glucose–insulin dynamics. In a recent issue of the Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β‐cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β‐cells.Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β‐cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β‐cells. Their multiomics approach might provide a deeper understanding of high glucose and translational regulation of genes involved in β‐cell insulin impairment caused by prolonged high‐glucose exposure.