A microdosing framework for absolute bioavailability assessment of poorly soluble drugs: A case study on cold‐labeled venetoclax, from chemistry to the clinic-Reference-Cited by-同舟云学术

A microdosing framework for absolute bioavailability assessment of poorly soluble drugs: A case study on cold‐labeled venetoclax, from chemistry to the clinic

Published:2021-10-27 Issue:1 Volume:15 Page:244-254
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical Translational Sci

Author:

Alaarg Amr¹,Menon Rajeev²,Rizzo David³,Liu Yemin⁴,Bien Jeffrey⁵,Elkinton Tricia⁶,Grieme Timothy⁷,Asmus Lutz R.⁸,Salem Ahmed Hamed²⁹^ORCID

Affiliation:

1. Drug Product Development AbbVie Inc. North Chicago Illinois USA

2. Clinical Pharmacology and Pharmacometrics AbbVie North Chicago Illinois USA

3. DMPK‐BA AbbVie Inc North Chicago Illinois USA

4. Development Sciences Analytical R&D AbbVie Inc. North Chicago Illinois USA

5. Development Sciences Program Management & Sourcing North Chicago Illinois USA

6. AbbVie Clinical Pharmacology Research Unit Grayslake Illinois USA

7. Process R&D AbbVie Inc. North Chicago Illinois USA

8. Drug Product Development AbbVie Deutschland GmbH & Co. KG Ludwigshafen Germany

9. Clinical Pharmacy Ain Shams University Cairo Egypt

Funder

Roche

Genentech

AbbVie

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13144

Reference34 articles.

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5. Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound—The Venetoclax Story

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