Population pharmacokinetic analysis to recommend the optimal dose of udenafil in patients with mild and moderate hepatic impairment

Author:

Kim Anhye1,Lee Jongtae1,Shin Donghoon1,Jung Yong Jin2,Bahng Mi Young3,Cho Joo-Youn1,Jang In-Jin1

Affiliation:

1. Department of Clinical Pharmacology and Therapeutics; Seoul National University College of Medicine and Hospital; Seoul South Korea

2. Department of Internal Medicine, SMG-SNU Boramae Medical Center; Seoul National University College of Medicine; Seoul South Korea

3. Department of Clinical Development; Dong-A ST Co., Ltd.; Seoul South Korea

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference18 articles.

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2. The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction;Gupta;J Clin Pharmacol,2005

3. An update on new oral PDE5 inhibitors for the treatment of erectile dysfunction;Palit;Nat Rev Urol,2010

4. Food and Drug Administration. Guidance for Industry Pharmacokinetics in patients with impaired hepatic function: study design, data analysis, and impact on dosing and labeling U.S 2003 http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072123.pdf

5. Comparison of phosphodiesterase type 5 (PDE5) inhibitors;Wright;Int J Clin Pract,2006

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