Autoimmune skin disorders and SARS‐CoV‐2 vaccination – a meta‐analysis

Author:

Hinterseher Julia1,Hertl Michael1,Didona Dario1

Affiliation:

1. Department of Dermatology and Allergology Philipps‐University Marburg Marburg Germany

Abstract

SummaryBackground and objectivesThe coronavirus SARS‐CoV‐2, which is the cause of COVID‐19 disease in infected patients, has led to an ongoing worldwide pandemic. Although SARS‐CoV‐2 vaccination had a dramatic positive effect on the course of COVID‐19, there has been increasing evidence of adverse effects after SARS‐CoV‐2 vaccination. This meta‐analysis highlights the association between SARS‐CoV‐2 vaccination and de novo induction or aggravation of inflammatory and autoimmune skin diseases.Material and methodsA systematic meta‐analysis of the literature on new onset or worsening of inflammatory and autoimmune diseases after SARS‐CoV‐2 vaccination was performed according to the PRISMA guidelines. The search strategy included following terms: “COVID‐19/SARS‐CoV‐2 vaccine bullous pemphigoid/pemphigus vulgaris/systemic lupus erythematosus/dermatomyositis/lichen planus/leukocytoclastic vasculitis.” Moreover, we describe representative cases from our dermatology department.ResultsThe database‐search in MEDLINE identified 31 publications on bullous pemphigoid, 24 on pemphigus vulgaris, 65 on systemic lupus erythematosus, nine on dermatomyositis, 30 on lichen planus, and 37 on leukocytoclastic vasculitis until June 30th, 2022. Severity and response to treatment varied among the described cases.ConclusionsOur meta‐analysis highlights a link between SARS‐CoV‐2 vaccination and new onset or worsening of inflammatory and autoimmune skin diseases. Moreover, the extent of disease exacerbation has been exemplified by cases from our dermatological department.

Publisher

Wiley

Subject

Dermatology

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