Transforming growth factor (TGF)-β signalling is increased in rheumatoid synovium but TGF-β blockade does not modify experimental arthritis
Author:
Affiliation:
1. Hospital 12 de Octubre, ‘i+12’, Instituto de Investigación, Madrid, Spain
2. DIGNA Biotech, Pamplona, Spain
3. Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain
Abstract
Funder
FER
RIER
Spanish Ministry of Economy and Competitiveness
Publisher
Oxford University Press (OUP)
Subject
Immunology,Immunology and Allergy
Link
https://academic.oup.com/cei/article-pdf/174/2/245/41788827/cei12179.pdf
Reference50 articles.
1. Analysis of the histologic variation of synovitis in rheumatoid arthritis;Rooney;Arthritis Rheum,1988
2. The transforming growth factor-beta family;Massague;Annu Rev Cell Biol,1990
3. TGF-beta signalling from cell membrane to nucleus through SMAD proteins;Heldin;Nature,1997
4. Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation;Moustakas;Immunol Lett,2002
5. Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease;Monteleone;J Clin Invest,2001
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