Risk for second primary cancers among pediatric and young adult melanoma survivors

Author:

Luu Yen1ORCID,Han Joseph2,Agarwal Aneesh2,Elkady Nadine1,Jaroonwanichkul Sandra1,Gulati Nicholas2,Gittler Julia3

Affiliation:

1. Department of Dermatology University of Missouri—Kansas City School of Medicine Kansas City Missouri USA

2. Department of Dermatology Icahn School of Medicine at Mount Sinai New York City New York USA

3. Department of Medicine, Division of Dermatology Albert Einstein College of Medicine and Montefiore Medical Center Bronx New York USA

Abstract

AbstractBackground/ObjectivesSecond primary cancers (SPCs) are a leading cause of morbidity and mortality among cancer survivors. In this study, we aimed to characterize the incidence of SPCs among pediatric and young adult survivors of CM.MethodsUsing the Surveillance, Epidemiology, and End Results Program data spanning 2000–2018, we calculated standardized incidence ratios (SIR) to assess SPC risk in all pediatric (0–18 years) and young adult (19–29 years) patients with a first primary cancer diagnosis of CM.ResultsOf 7,169 total CM survivors, 632 (8.82%) developed a SPC, corresponding to a 5‐fold increased risk (standardized incidence ratio [SIR] 4.98; 95% confidence interval [CI] 4.60–5.38) compared to the general population. There was a highly elevated risk for second primary melanoma across all age groups (SIR 32.5; 95% CI 29.7–35.6), constituting the majority of SPC diagnoses (N = 485). Infants diagnosed with CM before 1 year of age had the highest risk for any SPC (SIR 164; 95% CI 19.8–592) and young adults diagnosed at 25–29 years had the lowest risk (SIR 4.64; 95% CI 4.19–5.13). SPC incidence was highest within the first year of CM diagnosis (SIR 27.5; 95% CI 23.7–31.6) and progressively decreased with time.ConclusionsVariation exists in the incidence and type of SPC according to age among pediatric and young adult survivors of CM.

Publisher

Wiley

Subject

Dermatology,Pediatrics, Perinatology and Child Health

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