Affiliation:
1. Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine Oita Japan
2. Department of Comprehensive Surgery for Community Medicine Oita University Faculty of Medicine Oita Japan
Abstract
AimThe number of surgeries for pancreatic ductal adenocarcinoma (PDAC) in older adults has been rising. This study aimed to evaluate the technical and oncological safety of pancreatectomy for older adults aged ≥75 years with PDAC by retrospectively comparing their short‐ and long‐term outcomes with those of younger adults aged <75 years.MethodsData were collected from 117 patients who underwent pancreatectomy for PDAC in our department. The indication for surgery regarding patient characteristics was considered according to each patient's American Society of Anesthesiologists physical status and Eastern Cooperative Oncology Group Performance Status Scale. Data of older adults (n = 32) were compared with those of younger adults (n = 85), and comprised patient background, surgical factors, postoperative course, histopathological factors and prognostic factors. Additionally, prognostic nutritional index values preoperatively and at 1 and 6 months postoperatively were compared between the two groups.ResultsAlthough American Society of Anesthesiologists physical status and comorbidities were worse in older adults, there were no significant differences in surgical factors, postoperative courses and histopathological factors between the two groups. The overall complication rate tended to be higher in older adults (40.6%) than in younger adults (29.4%). There were no differences in median lengths of recurrence‐free survival and overall survival (older adults vs younger adults: 12 vs 13 months, P = 0.545, and 26 vs 20 months, P = 0.535, respectively) between the two groups. Furthermore, no significant differences were found in prognostic nutritional index preoperatively to 6 months after surgery.ConclusionWith careful determination of surgical indications, pancreatectomy for PDAC can be carried out with acceptable post‐pancreatectomy morbidity in younger adults. Geriatr Gerontol Int 2023; 23: 531–536.