Sensitivity and Reliability of Halothane-anaesthetizedMicrominipigsto Assess Risk of Drug-induced Long QT Syndrome

Author:

Cao Xin1,Wada Takeshi2,Nakamura Yuji2,Matsukura Suchitra2,Izumi-Nakaseko Hiroko2,Ando Kentaro12,Naito Atsuhiko T.12,Sugiyama Atsushi12

Affiliation:

1. Department of Pharmacology; Toho University Graduate School of Medicine; Ota-ku, Tokyo Japan

2. Department of Pharmacology; Faculty of Medicine; Toho University; Ota-ku, Tokyo Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science London

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Reference38 articles.

1. S7B nonclinical evaluation of the potential for delayed ventricular repolarization (QT Interval Prolongation) by human pharmaceuticals http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm074963.pdf

2. Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts;Sugiyama;Br J Pharmacol,2008

3. The utility of the minipig as an animal model in regulatory toxicology;Bode;J Pharmacol Toxicol Methods,2010

4. Microminipig, a non-rodent experimental animal optimized for life science research: preface;Kaneko;J Pharmacol Sci,2011

5. Microminipig, a non-rodent experimental animal optimized for life science research. In vivo proarrhythmia models of drug-induced long QT syndrome: development of chronic atrioventricular block model of microminipig;Sugiyama;J Pharmacol Sci,2011

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