Affiliation:
1. Bioinformatics, Institute of Biochemistry and Biology University of Potsdam Potsdam Germany
2. Systems Biology and Mathematical Modelling Max Planck Institute of Molecular Plant Physiology Potsdam Germany
3. Faculty of Biological and Environmental Sciences University of Helsinki Helsinki Finland
Abstract
AbstractAccumulating evidence for trade‐offs involving metabolic traits has demonstrated their importance in the evolution of organisms. Metabolic models with different levels of complexity have already been considered when investigating mechanisms that explain various metabolic trade‐offs. Here we provide a systematic review of modelling approaches that have been used to study and explain trade‐offs between: (i) the kinetic properties of individual enzymes, (ii) rates of metabolic reactions, (iii) the rate and yield of metabolic pathways and networks, (iv) different metabolic objectives in single organisms and in metabolic communities, and (v) metabolic concentrations. In providing insights into the mechanisms underlying these five types of metabolic trade‐offs obtained from constraint‐based metabolic modelling, we emphasize the relationship of metabolic trade‐offs to the classical black box Y‐model that provides a conceptual explanation for resource acquisition–allocation trade‐offs. In addition, we identify several pressing concerns and offer a perspective for future research in the identification and manipulation of metabolic trade‐offs by relying on the toolbox provided by constraint‐based metabolic modelling for single organisms and microbial communities.
Funder
Deutsche Forschungsgemeinschaft
Subject
Genetics,Ecology, Evolution, Behavior and Systematics
Cited by
2 articles.
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