Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma

Author:

Sehmi R.1,Smith S. G.1,Kjarsgaard M.1,Radford K.1,Boulet L.-P.2,Lemiere C.3,Prazma C. M.4,Ortega H.4,Martin J. G.5,Nair P.1

Affiliation:

1. Department of Medicine; McMaster University and Firestone Institute for Respiratory Health; St. Joseph's Healthcare; Hamilton ON Canada

2. Institut Universitaire de cardiologie et de pneumologie de Québec; Québec QC Canada

3. Division of Pneumologie; University of Montreal; Montreal QC Canada

4. GlaxoSmithKline; Research Triangle Park NC USA

5. Meakins-Christie Laboratories; Research Institute of the McGill University Health Center; Montreal QC Canada

Funder

GlaxoSmithKline

Father Sean O'Sullivan Postdoctoral Fellowship

Canada Research Chair in Airway Inflammometry

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference40 articles.

1. A look at the pathogenesis of asthma: the need for a change in direction;Holgate;Discov Med,2010

2. Can guideline-defined asthma control be achieved?;Bateman;Am J Respir Crit Care Med,2004

3. Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids;Leuppi;Am J Respir Crit Care Med,2001

4. Consistency of sputum eosinophilia in difficult to treat asthma: a 5-year follow-up study;Veen;J Allergy Clin Immunol,2009

5. Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and non-eosinophilic phenotypes;Lemière;J Allergy Clin Immunol,2006

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