Affiliation:
1. Division of Genetic Medicine, Vanderbilt University, Nashville, Tennessee
Abstract
Ion channels are critical for neuronal excitability and provide important targets for anticonvulsant drugs. In the past few years, several monogenetic epilepsies have been linked to mutations in genes encoding either voltage-gated or ligand-gated channels. The recognition that certain epilepsy syndromes are “channelopathies” initiates a new era in understanding the molecular pathophysiology of seizure disorders. This review summarizes recent advances related to this exciting area of investigation.
Cited by
49 articles.
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