From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder

Author:

Weleff Jeremy1ORCID,Nunes Julio C.1ORCID,Costa Gabriel P. A.2ORCID,Sofuoglu Mehmet13ORCID,MacLean R. Ross13ORCID,De Aquino Joao P.134ORCID

Affiliation:

1. Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA

2. Faculty of Medicine University of Ribeirão Preto Ribeirão Preto SP Brazil

3. VA Connecticut Healthcare System West Haven Connecticut USA

4. Clinical Neuroscience Research Unit Connecticut Mental Health Center New Haven Connecticut USA

Abstract

The rise of psychedelics in contemporary medicine has sparked interest in their potential therapeutic applications. While traditionally associated with countercultural movements and recreational use, recent research has shed light on the potential benefits of psychedelics in various mental health conditions. In this review, we explore the possible role of psychedelics in the management of chronic pain and opioid use disorder (OUD), 2 critical areas in need of innovative treatment options. Pain control remains a significant clinical challenge, particularly for individuals with OUD and those who receive long‐term opioid therapy who develop marked tolerance to opioid‐induced analgesia. Despite the magnitude of this problem, there is a scarcity of controlled studies investigating pain management alternatives for these populations. Drawing from preclinical and human evidence, we highlight the potential of psychedelics to act on shared neurobiological substrates of chronic pain and OUD, potentially reversing pain‐ and opioid‐induced neuroadaptations, such as central sensitization. We elaborate on the multifaceted dimensions of the pain experience (sensory, affective and cognitive) and their intersections that overlap with opioid‐related phenomena (opioid craving and withdrawal), hypothesizing how these processes can be modulated by psychedelics. After summarizing the available clinical research, we propose mechanistic insights and methodological considerations for the design of future translational studies and clinical trials, building on a shared clinical and neurobiological understanding of chronic pain and OUD. Our intention is to provide timely perspectives that accelerate the development and exploration of novel therapeutics for chronic pain and OUD amidst the escalating opioid crisis.

Funder

National Institute on Drug Abuse

Publisher

Wiley

Reference155 articles.

1. Drug overdose deaths in the United States, 2001‐2021;Spencer MR;NCHS Data Brief,2022

2. The triple wave epidemic: Supply and demand drivers of the US opioid overdose crisis

3. Vital signs: overdoses of prescription opioid pain relievers and other drugs among women—United States, 1999–2010;Mack KA;MMWR Morb Mortal Wkly Rep,2013

4. Pain and Substance-Related Pain-Reduction Behaviors among Opioid Dependent Individuals Seeking Methadone Maintenance Treatment

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