Biology of advanced uveal melanoma and next steps for clinical therapeutics

Author:

Luke Jason J.1,Triozzi Pierre L.2,McKenna Kyle C.3,Van Meir Erwin G.4,Gershenwald Jeffrey E.5,Bastian Boris C.6,Gutkind J. Silvio7,Bowcock Anne M.8,Streicher Howard Z.9,Patel Poulam M.10,Sato Takami11,Sossman Jeffery A.12,Sznol Mario13,Welch Jack9,Thurin Magdalena9,Selig Sara14,Flaherty Keith T.15,Carvajal Richard D.16

Affiliation:

1. Dana-Farber Cancer Institute; Harvard Medical School; Boston MA USA

2. Wake Forest University Cancer Center; Medical Center Boulevard; Winston-Salem NC USA

3. University of Pittsburgh Cancer Institute; Pittsburgh PA USA

4. School of Medicine; The Winship Cancer Institute of Emory University; Atlanta GA USA

5. University of Texas MD Anderson Cancer Center; Houston TX USA

6. University of California San Francisco Helen Diller Comprehensive Cancer Center; San Francisco CA USA

7. National Institute of Dental and Craniofacial Research; Bethesda MD USA

8. National Heart & Lung Institute; Imperial College; London UK

9. National Cancer Institute; Bethesda MD USA

10. University of Nottingham; Nottingham UK

11. The Kimmel Cancer Center; Thomas Jefferson University; Philadelphia PA USA

12. Vanderbilt-Ingram Cancer Center; Vanderbilt University; Nashville TN USA

13. Yale Cancer Center; Yale University; New Haven CT USA

14. Brigham and Woman's Hospital and the Melanoma Research Foundation; CURE OM; Washington DC USA

15. Massachusetts General Hospital Cancer Center; Harvard Medical School; Boston MA USA

16. Memorial-Sloan Kettering Cancer Center; New York NY USA

Funder

NIH

Samuel Waxman Cancer Research Foundation

Publisher

Wiley

Subject

Dermatology,General Biochemistry, Genetics and Molecular Biology,Oncology

Reference118 articles.

1. Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers;Abdel-Rahman;J. Med. Genet.,2011

2. Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease;Achberger;Mol. Immunol.,2014

3. Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target;All-Ericsson;Invest. Ophthalmol. Vis. Sci.,2002

4. Identification of unique MEK-dependent genes in GNAQ mutant uveal melanoma involved in cell growth, tumor cell invasion, and MEK-resistance;Ambrosini;Clin. Cancer Res.,2012

5. Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death;Ambrosini;Mol. Cancer Ther.,2013

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