Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2

Author:

Borsotti Patrizia1,Ghilardi Carmen2,Ostano Paola3,Silini Antonietta2,Dossi Romina1,Pinessi Denise1,Foglieni Chiara1,Scatolini Maria3,Lacal Pedro M.4,Ferrari Raffaele5,Moscatelli Davide5,Sangalli Fabio6,D'Atri Stefania4,Giavazzi Raffaella2,Bani Maria Rosa2,Chiorino Giovanna3,Taraboletti Giulia1

Affiliation:

1. Tumor Angiogenesis Unit; Department of Oncology; IRCCS - Istituto di Ricerche Farmacologiche Mario Negri; Bergamo Italy

2. Laboratory of Biology and Therapy of Metastasis; Department of Oncology; IRCCS - Istituto di Ricerche Farmacologiche Mario Negri; Milan Italy

3. Laboratory of Cancer Genomics; Fondo Edo ed Elvo Tempia Valenta; Biella Italy

4. Laboratory of Molecular Oncology; Istituto Dermopatico dell'Immacolata-IRCCS; Rome Italy

5. Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”; Politecnico di Milano; Milan Italy

6. Department of Biomedical Engineering; IRCCS - Istituto di Ricerche Farmacologiche Mario Negri; Bergamo Italy

Funder

Associazione Italiana per la Ricerca sul Cancro

Italian Ministry of Health

Publisher

Wiley

Subject

Dermatology,General Biochemistry, Genetics and Molecular Biology,Oncology

Reference46 articles.

1. The thrombospondins;Adams;Cold Spring Harb Perspect. Biol.,2011

2. Role of melanoma secreted thrombospondin-1 on induction of immunosuppressive regulatory T cells through CD47;Baumgartner;J. Cancer Mol.,2008

3. Matricellular proteins: extracellular modulators of cell function;Bornstein;Curr. Opin. Cell Biol.,2002

4. Analysis of microarray data using Z score transformation;Cheadle;J. Mol. Diagn.,2003

5. Expression of the thrombospondin 1 fragment 167-569 in C6 glioma cells stimulates tumorigenicity despite reduced neovascularization;Fraipont;Oncogene,2004

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