Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS

Author:

Fichna J.123,Sobczak M.3,Mokrowiecka A.4,Cygankiewicz A. I.5,Zakrzewski P. K.5,Cenac N.678,Sałaga M.3,Timmermans J.-P.9,Vergnolle N.678,Małecka-Panas E.4,Krajewska W. M.5,Storr M.1210

Affiliation:

1. Snyder Institute for Chronic Diseases; University of Calgary; Calgary AB Canada

2. Division of Gastroenterology; Department of Medicine; University of Calgary; Calgary AB Canada

3. Department of Biochemistry; Medical University of Lodz; Lodz Poland

4. Department of Digestive Tract Diseases; Faculty of Medicine; Medical University of Lodz; Lodz Poland

5. Department of Cytobiochemistry; Faculty of Biology and Environmental Protection; University of Lodz; Lodz Poland

6. Inserm U1043; Toulouse France

7. CNRS U5282; Toulouse France

8. Université de Toulouse, UPS; Centre de Physiopathologie de Toulouse Purpan (CPTP); Toulouse France

9. Department of Veterinary Sciences; Laboratory of Cell Biology and Histology; University of Antwerp; Antwerp Belgium

10. Division of Gastroenterology; Department of Medicine; Ludwig Maximilians University of Munich; Munich Germany

Funder

Deutsche Forschungsgemeinschaft

Polish Ministry of Science and Higher Education

University of Calgary Research Grant Committee

Publisher

Wiley

Subject

Gastroenterology,Endocrine and Autonomic Systems,Physiology

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