A prospective cohort study of a new electrosurgical unit for preventing colorectal post‐endoscopic submucosal dissection coagulation syndrome

Abstract

AbstractBackground and AimPost‐endoscopic submucosal dissection coagulation syndrome (PECS) is a recognized complication of colorectal endoscopic submucosal dissection (ESD); however, there is a lack of interventions for preventing PECS. We therefore conducted a prospective study to evaluate the utility of maXium, a novel electrosurgical unit, for preventing PECS.MethodsThis single‐center, prospective cohort study prospectively enrolled patients undergoing colorectal ESD. The voltage and power of the electrosurgical units were measured. PECS was defined as a visual analog scale (VAS) ≥ 30 mm, an increase of VAS ≥ 20 mm from baseline, body temperature ≥ 37.5°C, or white blood cell count ≥ 10 000/μL after ESD. PECS was classified into type I (without extra‐luminal air) and type II (with peri‐luminal air). The primary endpoint was the incidence of PECS. A sample size of 92 patients was required to ensure the upper limit of the 90% CI for the incidence of PECS was less than 15%.ResultsAt resistances greater than 400 Ω, the maXium unit allowed submucosal dissection with lower power than with the VIO300D unit. Ninety‐one patients meeting the inclusion criteria were included in the final study analysis. The incidence of PECS was 16% (90% CI, 10–23%), comprising type I (11%) and type II (5%) PECS. Simple extra‐luminal air without PECS was observed in 7% of patients.ConclusionUse of the maXium electrosurgical unit did not reduce the incidence of PECS after colorectal ESD; however, the maXium unit had equivalent performance to a conventional electrosurgical unit used for colorectal ESD.