Higher rates of triple-class virological failure in perinatally HIV-infected teenagers compared with heterosexually infected young adults in Europe

Author:

Judd A1ORCID,Lodwick R2,Noguera-Julian A345,Gibb DM1,Butler K6,Costagliola D7,Sabin C2,van Sighem A8,Ledergerber B9,Torti C10,Mocroft A2,Podzamczer D11,Dorrucci M12,De Wit S13,Obel N14,Dabis F1516,Cozzi-Lepri A2,García F17,Brockmeyer NH18,Warszawski J19,Gonzalez-Tome MI20,Mussini C21,Touloumi G22,Zangerle R23,Ghosn J2425,Castagna A26,Fätkenheuer G27,Stephan C28,Meyer L2930,Campbell MA31,Chene G151632,Phillips A2,

Affiliation:

1. MRC Clinical Trials Unit; University College London; London UK

2. Department of Infection and Population Health; University College London; London UK

3. Institut de Recerca Pediàtrica Hospital Sant Joan de Déu; Barcelona Spain

4. Departament de Pediatria; Universitat de Barcelona; Barcelona Spain

5. CIBER de Epidemiología y Salud Pública Ciberesp; Barcelona Spain

6. Department of Infectious Diseases and Immunology; Our Lady's Children's Hospital; Crumlin, Dublin Ireland

7. INSERM, UPMC Univ Paris 06, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136); Sorbonne Universités; Paris France

8. Stichting HIV Monitoring; Amsterdam The Netherlands

9. Division of Infectious Diseases and Hospital Epidemiology; University of Zurich; Zurich Switzerland

10. Unit of Infectious and Tropical Diseases, Department of Medical and Surgical Sciences; University “Magna Graecia”; Catanzaro Italy

11. HIV and STD Unit, Infectious Disease Service; Hospital Universitari de Bellvitge. L'Hospitalet; Barcelona Spain

12. Istituto Superiore di Sanità; Rome Italy

13. Département of Infectious Diseases, Centre Hospitalier Saint-Pierre; Université Libre de Bruxelles; Brussels Belgium

14. Department of Infectious Diseases; Copenhagen University Hospital, Rigshospitalet; Copenhagen Denmark

15. INSERM U1219 - Centre Inserm Bordeaux Population Health; Université de Bordeaux; Bordeaux France

16. ISPED, Centre INSERM U1219-Bordeaux Population Health; Université de Bordeaux; Bordeaux France

17. Clinical Microbiology Department, Complejo Hospitalario Universitario Granada; Instituto de Investigación Biosanitaria ibs.Granada; Granada Spain

18. Department of Dermatology, Venerology and Allergology, Center for Sexual Health and Medicine, St. Josef Hospital; Ruhr-Universität Bochum; Bochum Germany

19. INSERM CESP U1018, AP-HP Public Health Department; Université Paris-Sud, Université Paris-Saclay; Le Kremlin-Bicêtre Paris France

20. HIV and Paeds Infectious Diseases Department; Hospital 12 de Octubre Madrid Spain

21. Infectious Diseases Clinics; University Hospital; Modena Italy

22. Department Hygiene, Epidemiology & Medical Statistics, Medical School; National & Kapodistrian University of Athens; Athens Greece

23. Medical University Innsbruck; Innsbruck Austria

24. EA 7327, Faculté de Médecine site Necker; Université Paris Descartes, Sorbonne Paris Cité; Paris France

25. APHP, Unité Fonctionnelle de Thérapeutique en Immuno-Infectiologie; Hôpitaux Universitaires Paris Centre site Hôtel Dieu; Paris France

26. San Raffaele Scientific Institute; Vita-SaLute University; Milan Italy

27. Department I of Internal Medicine; University Hospital of Cologne; Cologne Germany

28. Second Medical Department, Infectious Diseases Unit; Goethe-University Hospital; Frankfurt Germany

29. INSERM CESP U1018; Université Paris-Sud, Université Paris-Saclay; Paris France

30. AP-HP Public Health Department; Le Kremlin-Bicêtre; Paris France

31. Centre for Health and Infectious Disease Research; University of Copenhagen; Copenhagen Denmark

32. CHU de Bordeaux, Pole de sante publique, Service d'information medicale; Bordeaux France

Funder

Medical Research Council

Agence Nationale de Recherches sur le Sida et les Hepatites Virales

HIV Monitoring Foundation, The Netherlands

Augustinus Fonden

Seventh Framework Programme

EuroCoord

Swiss Bridge Foundation

Publisher

Wiley

Subject

Pharmacology (medical),Infectious Diseases,Health Policy

Reference26 articles.

1. The challenges of success: adolescents with perinatal HIV infection;Mofenson;J Int AIDS Soc,2013

2. When to start, what to start and other treatment controversies in pediatric HIV infection;Turkova;Paediatr Drugs,2012

3. Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life;Bamford;HIV Med,2015

4. (PLATO II) project team. Risk of triple-class virological failure in children with HIV: a retrospective cohort study;The Pursuing Later Treatment Options II;Lancet,2011

5. (COHERE) study group. Response to combination antiretroviral therapy: variation by age;Collaboration of Observational HIV Epidemiological Research Europe;AIDS,2008

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