Autologous cell transplant as a treatment for stable segmental vitiligo: a systematic review

Author:

Souroujon Ariela A.1ORCID,Guttman Ilana1ORCID,Levin Nathalie1ORCID,Capuano Galia1ORCID,Reyes Salcedo Cesar Alejandro2ORCID,García Paulina1ORCID

Affiliation:

1. Universidad Anahauc México Huixquilucan Mexico

2. Dermatology Clinic Dermacares Mexico City Mexico

Abstract

AbstractObjectiveThis systematic review provides a comprehensive analysis of the efficacy of autologous cell transplant as a therapeutic approach for stable segmental vitiligo. Vitiligo poses significant challenges for healthcare professionals in terms of treatment selection. Autologous cell transplant has emerged as a promising modality for managing vitiligo, with cultured and noncultured transplants being considered when determining the patient's treatment approach. There is little knowledge and literature on the subject, so we analyze the different studies.MethodUsing online medical literature databases and the PRISMA guidelines, six out of 60 articles met the acceptance criteria to be analyzed, emphasizing the lack of current literature on this subject.ResultsAutologous cell transplant achieves excellent pigmentation rates for many body parts. We found that cultivated cells had better results than noncultivated ones. Both types of treatments could pigment 80% or more where needed.ConclusionThis review highlights the importance of autologous cell transplant as a new and reliable tool for the treatment of stable segmental vitiligo, cultured transplants being the most effective. By employing autologous cell transplant, the repigmentation rate is notably high and consistently achievable. Although its cost and logistical complexities hinder the current accessibility to this therapy, efforts are being made to enhance its availability, and its scope is expected to expand further. More studies are needed to understand this therapy method in other kinds of vitiligo.

Publisher

Wiley

Subject

Dermatology

Reference20 articles.

1. El vitíligo, una enfermedad estigmática: un recorrido a través de su historia Vitiligo, a stigmatized disease: a journey throughout its history Historia de la Dermatología;Rodríguez‐Cerdeira C;Med Cutan Iber Lat Am,2011

2. CristinaA TrémulL PilarM SalasS.Vitíligo: principales opciones terapéuticas Vitiligo: main therapeutic options [Internet]. Available from:https://www.medigraphic.com/pdfs/cutanea/mc‐2006/mc062i.pdf

3. Treatment of vitiligo by transplantation of cultured pure melanocyte suspension: analysis of 120 cases

4. Autologous melanocyte-keratinocyte suspension in the treatment of vitiligo

5. Non-cultured melanocyte/keratinocyte transplantation for the treatment of stable vitiligo on the face: report of two cases

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