An A666G mutation in transmembrane helix 5 of the yeast multidrug transporter Pdr5 increases drug efflux by enhancing cooperativity between transport sites-Reference-Cited by-同舟云学术

An A666G mutation in transmembrane helix 5 of the yeast multidrug transporter Pdr5 increases drug efflux by enhancing cooperativity between transport sites

Published:2019-07-23 Issue:4 Volume:112 Page:1131-1144
ISSN:0950-382X
Container-title:Molecular Microbiology
language:en
Short-container-title:Mol Microbiol

Author:

Arya Nidhi¹,Rahman Hadiar¹,Rudrow Andrew¹,Wagner Manuel²,Schmitt Lutz²^ORCID,Ambudkar Suresh V.³,Golin John¹^ORCID

Affiliation:

1. The Department of Biology Catholic University of America Washington DC 20064USA

2. Institute of Biochemistry Heinrich‐Heine‐Universitat Düsseldorf Düsseldorf Germany

3. The Laboratory of Cell Biology, Center for Cancer Research, NCI NIH Bethesda MD 20892USA

Funder

National Science Foundation

National Institutes of Health

Publisher

Wiley

Subject

Molecular Biology,Microbiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.14351

Reference35 articles.

1. The Signaling Interface of the Yeast Multidrug Transporter Pdr5 Adopts a Cis Conformation, and There Are Functional Overlap and Equivalence of the Deviant and Canonical Q-Loop Residues

2. Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine

3. The Q-loop Disengages from the First Intracellular Loop during the Catalytic Cycle of the Multidrug ABC Transporter BmrA

4. The Transmission Interface of the Saccharomyces cerevisiae Multidrug Transporter Pdr5: Val-656 Located in Intracellular Loop 2 Plays a Major Role in Drug Resistance

5. A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Fungal Drug Response and Antimicrobial Resistance;Journal of Fungi;2023-05-12

2. Residues forming the gating regions of asymmetric multidrug transporter Pdr5 also play roles in conformational switching and protein folding;Journal of Biological Chemistry;2022-12

3. A New Twist in ABC Transporter Mediated Multidrug Resistance – Pdr5 is a Drug/proton Co-transporter;Journal of Molecular Biology;2022-07

4. How fungal multidrug transporters mediate hyper resistance through DNA amplification and mutation;Molecular Microbiology;2022-06-06

5. A new twist in ABC transporter mediated multidrug resistance – Pdr5 is a drug/proton co-transporter;2021-05-26