Prescribing of antivirals for COVID‐19 in a South Australian local health network according to statewide guidelines

Author:

Al Naji Hiba1ORCID,Inglis Joshua M.1,Tucker Emily2,Rowett Debra3,Larcombe Rebecca4,Medlin Sophie4,Mangoni Arduino A.1,Thynne Tilenka1

Affiliation:

1. Department of Clinical Pharmacology Flinders Medical Centre and Flinders University Adelaide South Australia Australia

2. Infectious Diseases Unit Flinders Medical Centre Adelaide South Australia Australia

3. Drug and Therapeutics Information Service, Southern Adelaide Local Health Network Adelaide South Australia Australia

4. Pharmacy Services, Flinders Medical Centre, SA Pharmacy Adelaide South Australia Australia

Abstract

AbstractAntiviral drugs were rapidly implemented into clinical practice for the treatment of high‐risk patients with COVID‐19, prompting the development of statewide guidelines. This South‐Australian study reviewed guideline adherence, assessed prescribing patterns and highlighted the inappropriate management of relative drug–drug interactions and dosing for renal function. Additionally, it evaluated the impact of inappropriate antiviral drug use and suggested methods to improve quality use of medicines.

Publisher

Wiley

Reference15 articles.

1. Oral antivirals for mild‐moderate COVID‐19: a panacea or a logistical and clinical conundrum?;Coombes ID;Aust Prescr,2022

2. Guidelines AGDoHaACT.TGA provisionally approves two oral COVID‐19 treatments molnupiravir (LAGEVRIO) and nirmatrelvir + ritonavir (PAXLOVID). In: Administration TG ed. Available from URL:https://www.tga.gov.au/news/media-releases/tga-provisionally-approves-two-oral-covid-19-treatments-molnupiravir-lagevrio-and-nirmatrelvir-ritonavir-paxlovid2022

3. 2 CIDSM.COVID‐19: Treatment Recommendations for Hospitalised Adult Patients. In: CALHN Drugs and Therapeutics Committee C‐MAG ed. 1 ed2022:37.

4. Liverpool Uo.Covid‐19 Drug Interactions; 2022. Available from URL:https://www.covid19-druginteractions.org/

5. Impact of Guideline Adherence on Outcomes in Patients Hospitalized with Community-Acquired Pneumonia (CAP) in Hungary: A Retrospective Observational Study

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