ANZTCT consensus position statement on ruxolitinib in steroid‐refractory acute and chronic graft‐versus‐host disease

Author:

Hamad Nada123ORCID,Bilmon Ian4,Chee Lynette56,Henden Andrea7,Johnston Anna8,Purtill Duncan910,Bajel Ashish56,Tey Siok‐Keen7,Yeung David1112,Cole Theresa13,Lewis Clinton14,Butler Jason7

Affiliation:

1. St Vincent's Hospital Sydney Sydney New South Wales Australia

2. School of Clinical Medicine UNSW Medicine & Health Sydney New South Wales Australia

3. School of Medicine Sydney University of Notre Dame Sydney New South Wales Australia

4. Westmead Hospital Sydney New South Wales Australia

5. Peter MacCallum Cancer Centre Melbourne Victoria Australia

6. Royal Melbourne Hospital Melbourne Victoria Australia

7. Royal Brisbane and Women's Hospital Brisbane Queensland Australia

8. Royal Hobart Hospital Hobart Tasmania Australia

9. Fiona Stanley Hospital Perth Western Australia Australia

10. PathWest Laboratory Medicine Perth Western Australia Australia

11. Royal Adelaide Hospital Adelaide South Australia Australia

12. South Australian Health and Medical Research Institute Adelaide South Australia Australia

13. Royal Children's Hospital Melbourne Victoria Australia

14. Auckland City Hospital Auckland New Zealand

Abstract

AbstractThis position paper provides an overview of the assessment and management of both acute and chronic graft‐versus‐host disease (GvHD). There is a focus on the use of ruxolitinib, a selective inhibitor of Janus kinase (JAK)1 and JAK2, for the treatment of corticosteroid‐refractory and corticosteroid‐dependent GvHD.

Funder

Novartis Australia

Publisher

Wiley

Subject

Internal Medicine

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