Pharmacokinetics of Sugammadex Dosed by Actual and Ideal Body Weight in Patients With Morbid Obesity Undergoing Surgery

Author:

Mostoller Kate1,Wrishko Rebecca2,Maganti Lata3,Herring W. Joseph1,Zutphen‐van Geffen Mariëlle4

Affiliation:

1. Department of Clinical Research Merck & Co., Inc. Kenilworth New Jersey USA

2. Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism Merck & Co., Inc. Kenilworth New Jersey USA

3. Department of Biostatistics Merck & Co., Inc. Kenilworth New Jersey USA

4. Certara Strategic Consulting Oss The Netherlands

Funder

Merck Sharp and Dohme

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference36 articles.

1. A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

2. Reversal of Meeting Abstracts and Simultaneous Increase in Plasma Rocuronium Concentration after the Intravenous Infusion of the Novel Reversal Agent Org 25969

3. Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial

4. Reversal of Profound Rocuronium-induced Blockade with Sugammadex

5. Sugammadex Provides Faster Reversal of Vecuronium-Induced Neuromuscular Blockade Compared with Neostigmine: A Multicenter, Randomized, Controlled Trial

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