Equivocal (HER2 IHC 2+) breast carcinomas: gene-protein assay testing reveals association between genetic heterogeneity, individual cell amplification status and potential treatment benefits
Author:
Affiliation:
1. Department of Oncology and Pathology; Lund University; Lund Sweden
2. Department for Women's and Children's Health; Uppsala University; Uppsala Sweden
3. Pathology and Cytology; County Hospital Falun; Falun Sweden
Publisher
Wiley
Subject
General Medicine,Histology,Pathology and Forensic Medicine
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/his.13733/fullpdf
Reference33 articles.
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3. Predicting degree of benefit from adjuvant trastuzumab in NSABP trial B-31;Pogue-Geile;J. Natl Cancer Inst.,2013
4. A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections;Nitta;Diagn. Pathol.,2012
5. Dual HER2 gene protein assay: focused study of breast cancers with 2+ immunohistochemical expression;Li;Am. J. Clin. Pathol.,2015
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3. Somatic mutations and copy number variations in breast cancers with heterogeneousHER2amplification;Molecular Oncology;2020-04
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