Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1
Author:
Affiliation:
1. College of Pharmacy; Integrated Research Institute of Pharmaceutical Sciences; The Catholic University of Korea; Bucheon Korea
2. Division of Biotechnology; College of Life Sciences and Biotechnology; Korea University; Seoul Korea
Funder
National Research Foundation of Korea
Publisher
Wiley
Subject
Immunology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/imm.12373/fullpdf
Reference16 articles.
1. RIG-I-like receptors: cytoplasmic sensors for non-self RNA;Kato;Immunol Rev,2011
2. Cell type-specific involvement of RIG-I in antiviral response;Kato;Immunity,2005
3. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses;Kato;Nature,2006
4. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses;Yoneyama;Nat Immunol,2004
5. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction;Kawai;Nat Immunol,2005
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