Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study

Author:

McDonald Rebecca1ORCID,Lorch Ulrike2,Woodward Jo3,Bosse Björn4,Dooner Helen3,Mundin Gill3,Smith Kevin3,Strang John1

Affiliation:

1. National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience; King's College London; London UK

2. Richmond Pharmacology Ltd; Croydon University Hospital (Woodcroft Wing); Croydon UK

3. Mundipharma Research Ltd; Cambridge Science Park; Cambridgeshire UK

4. Mundipharma Research GmbH and Co. KG; Limburg Germany

Funder

Mundipharma Research Ltd, Cambridge, UK

Publisher

Wiley

Subject

Psychiatry and Mental health,Medicine (miscellaneous)

Reference30 articles.

1. United Nations Office on Drugs and Crime (UNODC) World Drug Report 2016 https://www.unodc.org/wdr2016/ http://www.webcitation.org/6u56T1R41

2. World Health Organization (WHO) Community Management of Opioid Overdose 2014 http://apps.who.int/iris/bitstream/10665/137462/1/9789241548816_eng.pdf?ua=1&ua=1 http://www.webcitation.org/6qHBtnGWj

3. Take-home naloxone: the next steps. Comments on Strang et al.'s ‘Preventing opiate overdose fatalities with take-home naloxone: pre-launch study of possible impact and acceptability’;Strang;Addiction,1999

4. Saved by the nose: bystander-administered intranasal naloxone hydrochloride for opioid overdose;Doe-Simkins;Am J Public Health,2009

5. Clinical provision of improvised nasal naloxone without experimental testing and without regulatory approval: imaginative shortcut or dangerous bypass of essential safety procedures?;Strang;Addiction,2016

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