FIB‐4 index is associated with mortality in critically ill patients with alcohol use disorder: Analysis from the MIMIC‐IV database

Abstract

AbstractBackgroundThe relationship between fibrosis‐4 (FIB‐4) index and all‐cause mortality in critically ill patients with alcohol use disorder (AUD) is unclear. The present study aimed to investigate the predictive ability of FIB‐4 for all‐cause mortality in critically ill AUD patients and the association between them.MethodsA total of 2528 AUD patients were included using the Medical Information Mart for Intensive Care IV (MIMIC‐IV) database. FIB‐4 was calculated for each patient using the existing formula. The patients were equally divided into four groups based on the quartiles of FIB‐4. Multivariate logistic regression and Cox proportional hazard model were used to evaluate the association of FIB‐4 with in‐hospital mortality, 28‐day mortality and 1‐year mortality. Kaplan–Meier curves were used to analyse the incidence of 28‐day mortality among four groups.ResultsFIB‐4 was positively associated with 28‐day mortality of AUD patients with hazard ratio (HR) of 1.354 [95% confidence interval (CI) 1.192–1.538]. There were similar trends in the in‐hospital mortality [odds ratio (OR): 1.440, 95% CI (1.239–1.674)] and 1‐year mortality [HR: 1.325, 95% CI (1.178–1.490)].ConclusionIncreased FIB‐4 is associated with greater in‐hospital mortality, 28‐day mortality and 1‐year mortality in critically ill AUD patients.