Continuous delivery of naltrexone and nalmefene leads to tolerance in reducing alcohol drinking and to supersensitivity of brain opioid receptors
Author:
Affiliation:
1. Department of Pharmacology, Faculty of Medicine; University of Helsinki; Finland
2. Department of Pharmacology, Yong Loo Lin School of Medicine; National University of Singapore; Singapore
Funder
Finnish Foundation for Alcohol Studies
Lundbeck Finland
Suomen Akatemia
Publisher
Wiley
Subject
Psychiatry and Mental health,Pharmacology,Medicine (miscellaneous)
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/adb.12393/fullpdf
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4. Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum;Atwood;Nat Neurosci,2014
5. Chronic naltrexone increases opiate binding in brain and produces supersensitivity to morphine in the locus coeruleus of the rat;Bardo;Brain Res,1983
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