Metabolic alterations in patients with Helicobacter pylori‐related gastritis: The H. pylori‐gut microbiota‐metabolism axis in progression of the chronic inflammation in the gastric mucosa

Author:

Zang Hongmin12ORCID,Wang Jin3,Wang Huijie2,Guo Jiaxuan2,Li Yuchan2,Zhao Yinuo4,Song Jinzhong12,Liu Fengshuang15,Liu Xuzhao6,Zhao Yubin167

Affiliation:

1. Hebei University of Chinese Medicine Shijiazhuang China

2. The Traditional Chinese Medicine Hospital of Shijiazhuang Shijiazhuang China

3. Dongzhimen Hospital Beijing University of Chinese Medicine Beijing China

4. School of Biological Sciences, Faculty of Biology, Medicine and Health The University of Manchester Manchester UK

5. Hebei Academy of Traditional Chinese Medicine Shijiazhuang China

6. North China University of Science and Technology Tangshan China

7. Shijiazhuang People's Hospital Shijiazhuang China

Abstract

AbstractPurposeTo characterize the serum metabolism in patients with Helicobacter pylori‐positive and H. pylori‐negative gastritis.MethodsClinical data and serum gastric function parameters, PGI (pepsinogen I), PGII, PGR (PGI/II), and G‐17 (gastrin‐17) of 117 patients with chronic gastritis were collected, including 57 H. pylori positive and 60 H. pylori negative subjects. Twenty cases in each group were randomly selected to collect intestinal mucosa specimens and serum samples. The gut microbiota profiles were generated by 16S rRNA gene sequencing, and the serum metabolites were analyzed by a targeted metabolomics approach based on liquid chromatography–mass spectrometry (LC–MS) technology.ResultsAltered expression of 20 metabolites, including isovaleric acid, was detected in patients with HPAG. Some taxa of Bacteroides, Fusobacterium, and Prevotella in the gut microbiota showed significant correlations with differentially expressed metabolites between H. pylori positive and H. pylori negative individuals. As a result, an H. pylori‐gut microbiota‐metabolism (HGM) axis was proposed.ConclusionHelicobacter pylori infection may influence the progression of mucosal diseases and the emergence of other complications in the host by altering the gut microbiota, and thus affecting the host serum metabolism.

Funder

National Basic Research Program of China

Publisher

Wiley

Subject

Infectious Diseases,Gastroenterology,General Medicine

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