Affiliation:
1. Faculty of Medicine University of Oslo Oslo Norway
2. Division of Obstetrics and Gynecology Oslo University Hospital Oslo Norway
3. School of Health Sciences Kristiania University College Oslo Norway
4. Department of Psychology University of Oslo Oslo Norway
Abstract
AbstractParacetamol is used by more than 50% of women worldwide during pregnancy; headache representing the most frequent indication. Several studies report that long‐term exposure to paracetamol in utero is associated with adverse neurodevelopmental outcomes in children, indicating a dose–response effect. However, less or no risk is found to be associated with short‐term exposure. Paracetamol most likely crosses the placenta through passive diffusion, and there are several possible mechanisms for how paracetamol might affect fetal brain development. Although the literature suggests an association between prenatal paracetamol exposure and neurodevelopmental outcomes, the role of confounders cannot be ruled out. Consequently, as a precaution, we believe that pregnant women should be recommended ideally to only use paracetamol to treat conditions that might harm the fetus, such as severe pain or a high fever. This Comment aims to put focus on the potential fetal risks of paracetamol exposure in utero.
Subject
Obstetrics and Gynecology,General Medicine
Cited by
5 articles.
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