Living donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference

Author:

Jesse Michelle T.1ORCID,Jackson Whitney E.2ORCID,Liapakis AnnMarie3ORCID,Ganesh Swaytha4,Humar Abhinav4,Goldaracena Nicolas5ORCID,Levitsky Josh6,Mulligan David7ORCID,Pomfret Elizabeth A.8,Ladner Daniela P.6ORCID,Roberts John P.9,Mavis Alisha10,Thiessen Carrie11ORCID,Trotter James12,Winder Gerald Scott13ORCID,Griesemer Adam D.14ORCID,Pillai Anjana15ORCID,Kumar Vineeta16ORCID,Verna Elizabeth C.17ORCID,LaPointe Rudow Dianne18ORCID,Han Hyosun H.19,

Affiliation:

1. Transplant Institute Henry Ford Health System Detroit Michigan USA

2. Division of Gastroenterology and Hepatology University of Colorado Aurora Colorado USA

3. Yale School of Medicine and Yale New Haven Transplant Center New Haven Connecticut USA

4. Thomas E Starzl Transplant Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA

5. Division of Transplant Surgery University of Virginia Health System Charlottesville Virginia USA

6. Comprehensive Transplant Center Northwestern University Feinberg School of Medicine Chicago Illinois USA

7. Division of Transplant Surgery Yale University New Haven Connecticut USA

8. Transplant Surgery University of Colorado Aurora Colorado USA

9. UCSF Department of Surgery San Francisco California USA

10. Pediatric Gastroenterology, Hepatology, and Nutrition Duke University Health Durham North Carolina USA

11. University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA

12. Transplant Hepatology Baylor University Medical Center Dallas Texas USA

13. Department of Psychiatry University of Michigan Ann Arbor Michigan USA

14. Department of Surgery NYU Langone Heath New York New York USA

15. Department of Internal Medicine University of Chicago Medicine Chicago Illinois USA

16. Department of Medicine Division of Nephrology/Transplant University of Alabama at Birmingham Birmingham Alabama USA

17. Center for Liver Disease and Transplantation Columbia University New York New York USA

18. Recanati/Miller Transplantation Institute Mount Sinai Hospital New York New York USA

19. Division of Gastrointestinal and Liver Diseases, Keck School of Medicine University of Southern California Los Angeles California USA

Abstract

AbstractIntroductionLiving donor liver transplantation (LDLT) is a promising option for mitigating the deceased donor organ shortage and reducing waitlist mortality. Despite excellent outcomes and data supporting expanding candidate indications for LDLT, broader uptake throughout the United States has yet to occur.MethodsIn response to this, the American Society of Transplantation hosted a virtual consensus conference (October 18–19, 2021), bringing together relevant experts with the aim of identifying barriers to broader implementation and making recommendations regarding strategies to address these barriers. In this report, we summarize the findings relevant to the selection and engagement of both the LDLT candidate and living donor. Utilizing a modified Delphi approach, barrier and strategy statements were developed, refined, and voted on for overall barrier importance and potential impact and feasibility of the strategy to address said barrier.ResultsBarriers identified fell into three general categories: 1) awareness, acceptance, and engagement across patients (potential candidates and donors), providers, and institutions, 2) data gaps and lack of standardization in candidate and donor selection, and 3) data gaps regarding post‐living liver donation outcomes and resource needs.ConclusionsStrategies to address barriers included efforts toward education and engagement across populations, rigorous and collaborative research, and institutional commitment and resources.

Publisher

Wiley

Subject

Transplantation

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