Plasma concentrations and sedative effects of a dexmedetomidine, midazolam, and butorphanol combination after transnasal administration in healthy rabbits

Author:

Santangelo B.1,Micieli F.1,Marino F.2,Reynaud F.3,Cassandro P.4,Carfora A.4,Petrella R.4,Borriello R.4,Cataldi M.5,Vesce G.1

Affiliation:

1. Department of Veterinary Medicine and Animal Productions; University of Napoli Federico II; Napoli Italy

2. Clinica veterinaria Animalia srls; Aversa Caserta Italy

3. Clinica veterinaria Sannio; Sant'Angelo a Cupolo; Benevento Italy

4. Department of Experimental Medicine; Laboratory of Forensic Toxicology; School of Medicine; Second University of Napoli; Napoli Italy

5. Department of Neuroscience; Reproductive and Odontostomatologic Sciences; University of Napoli Federico II; Napoli Italy

Publisher

Wiley

Subject

General Veterinary,Pharmacology

Reference21 articles.

1. Evaluation of sedation and clinical effects of midazolam with ketamine or dexmedetomidine in pet rabbits;Bellini;The Veterinary Record,2014

2. A comparison of the effects on respiratory carbon dioxide response, arterial blood pressure, and heart rate of dexmedetomidine, propofol, and midazolam in sevoflurane-anesthetized rabbits;Chang;Anesthesia and Analgesia,2009

3. Plasma concentrations of dexmedetomidine following intravenous dosing in rabbit;Geyer;Review and Evaluation of Pharmacology/Toxicology Data,1999

4. Nasal drug administration: potential for targeted central nervous system delivery;Graff;Journal of Pharmaceutical Sciences,2005

5. Comparison of sedative effects induced by medetomidine, medetomidine-midazolam and medetomidine-butorphanol in dogs;Hayashi;Journal of Veterinary Medical Science,1994

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