5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1

Author:

Altieri Paola1,Murialdo Roberto2,Barisione Chiara1,Lazzarini Edoardo1,Garibaldi Silvano1,Fabbi Patrizia1,Ruggeri Clarissa1,Borile Silvia3,Carbone Federico45ORCID,Armirotti Andrea6,Canepa Marco13,Ballestrero Alberto2,Brunelli Claudio13,Montecucco Fabrizio457,Ameri Pietro13ORCID,Spallarossa Paolo13

Affiliation:

1. Laboratory of Cardiovascular Biology, Department of Internal Medicine; University of Genova; Genova Italy

2. Oncology Unit; IRCCS AOU San Martino-IST; Genova Italy

3. Cardiovascular Disease Unit; IRCCS AOU San Martino-IST; Genova Italy

4. First Clinic of Internal Medicine; IRCCS AOU San Martino - IST; Genova Italy

5. Department of Internal Medicine; University of Genova; Genova Italy

6. Drug Discovery and Development Department; Italian Institute of Technology (IIT); Genova Italy

7. Centre of Excellence for Biomedical Research (CEBR); University of Genova; Genova Italy

Publisher

Wiley

Subject

Pharmacology

Reference49 articles.

1. DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status;Adamsen;Int J Oncol,2011

2. The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors;Alexander;Br J Pharmacol,2015a

3. The Concise Guide to PHARMACOLOGY 2015/16: Enzymes;Alexander;Br J Pharmacol,2015b

4. Testosterone antagonizes doxorubicin-induced senescence of cardiomyocytes;Altieri;J Am Heart Assoc,2016

5. Integrative proteomics and targeted transcriptomics analyses in cardiac endothelial cells unravel mechanisms of long-term radiation-induced vascular dysfunction;Azimzadeh;J Proteome Res,2015

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