Biochemical characterization of <scp>Jr(a−)</scp> blood type‐related <scp>ABCG2</scp> variants: <scp>Arg147Trp</scp> and <scp>Ser572Arg</scp> disrupt the plasma membrane localization of <scp>ABCG2</scp>-Reference-Cited by-同舟云学术

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Biochemical characterization of Jr(a−) blood type‐related ABCG2 variants: Arg147Trp and Ser572Arg disrupt the plasma membrane localization of ABCG2

Published:2024-02 Issue:2 Volume:64 Page:412-414
ISSN:0041-1132
Container-title:Transfusion
language:en
Short-container-title:Transfusion

Author:

Toyoda Yu¹²^ORCID,Matsuo Hirotaka²,Tanaka Mitsunobu³,Stiburkova Blanka⁴⁵,Takada Tappei¹^ORCID

Affiliation:

1. Department of Pharmacy The University of Tokyo Hospital Bunkyo‐ku Tokyo Japan

2. Department of Integrative Physiology and Bio‐Nano Medicine National Defense Medical College Tokorozawa Saitama Japan

3. Japanese Red Cross Kinki Block Blood Center Ibaraki Osaka Japan

4. Department of Molecular Biology and Immunogenetics Institute of Rheumatology Prague Czech Republic

5. Department of Paediatric Medicine and Inherited Metabolic Disorders 1st Medical Faculty of Charles University and General University Hospital Prague Czech Republic

Funder

Gout and Uric Acid Foundation

Japan Society for the Promotion of Science

Takeda Science Foundation

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/trf.17625

Reference6 articles.

1. A new genetic background for the Jr(a-) blood group phenotype caused by the ABCG2*439T allele encoding a p.Arg147Trp change

2. The JR blood group system: identification of alleles that alter expression

3. Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior

4. Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations

5. Structure of the human multidrug transporter ABCG2

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